This page helps you compare tretinoin cream and gel in 0.025%, 0.05% and 0.1% strengths, then find the products that match each format. It is for UK shoppers researching where to buy tretinoin cream online, including customers replacing a product they already know. Tretinoin is prescription-only in the UK, while this retailer sells internationally manufactured stock through an international retail model. Read the safety information carefully and speak with a pharmacist or doctor before using tretinoin if you are unsure.

Compare tretinoin strengths and formats

The percentage describes the concentration of tretinoin in the product. Cream and gel are different formulations, so the same percentage should not be assumed to feel identical on the skin. The table shows the tube sizes we currently stock.

Strength and formatTypical roleWho it may suitWho should be cautiousTube sizes stocked
0.025% creamLower-strength cream commonly considered when starting, or when a cream texture is preferredPeople advised to begin with a lower concentration who prefer a cream baseAnyone with an active flare of eczema, damaged skin, marked sensitivity or an uncertain diagnosis30g
0.025% gelLower-strength gel option for people who prefer a lighter formulationPeople familiar with gel textures, or advised that a gel is suitablePeople prone to dryness, stinging or irritation, and anyone applying it to broken or eczema-prone skin20g
0.05% creamMid-strength cream optionExisting tretinoin users who tolerate a cream formulation, subject to professional adviceNew users, sensitive or dry skin, and anyone already using several irritating products30g
0.05% gelMid-strength gel optionExisting users who tolerate tretinoin and prefer a lighter formulationDry or reactive skin, or anyone increasing strength too quickly20g
0.1% creamHigher-strength option for experienced users who have established tolerancePeople with prior tretinoin experience, advised that this concentration is appropriateNew users, sensitive or damaged skin, and anyone with persistent irritation20g

0.025% tretinoin

0.025% is the lowest concentration we stock. It is often the concentration people investigate when they want to introduce tretinoin gradually, but the correct choice depends on the product, the condition being treated, other skincare and personal tolerance. We stock it as a 30g cream and a 20g gel.

Tretin 0.025% Tretinoin Cream 30g
A-Ret 0.025% Tretinoin Gel 20g

0.05% tretinoin

The 0.05% range includes both a cream and a gel. The cream comes in a 30g tube. The gel has its own product listing, so check that page for the current tube size, ingredients, storage information and expiry details before ordering. If you are new to tretinoin, ask a pharmacist or doctor about strength and frequency.

Tretin 0.05% Tretinoin Cream 30g
Tretinoin 0.05% Gel

0.1% tretinoin

0.1% is the highest strength we stock. It should not be treated as a default upgrade, and a higher percentage can be harder to tolerate. The listed options are 20g creams from the Tretin, Acnelyse and Tretimaxx ranges. Review the label and expiry before use, particularly if you are replacing a familiar product with a different brand.

Tretinoin 0.1% Cream 20g
Acnelyse 0.1% Tretinoin Cream 20g
Tretimaxx 0.1% Tretinoin Cream 20g

Where our stock comes from

Our tretinoin products are internationally manufactured and supplied through an international retail model. The product name, brand, strength, tube size, batch details and expiry information vary by item. Our ranges include A-Ret, Acnelyse, Tretin and Tretimaxx. Where a listing does not identify the legal manufacturer, we say so rather than inventing one.

Before dispatch we check that the item matches the order, the packaging is present and not visibly damaged, the strength and format correspond with the listing, and the printed batch and expiry details are readable on the packaging. Check the product when it arrives. Do not use it if the seal, tube, label or packaging appears damaged, altered or inconsistent with the listing. Contact us before opening it.

Tretinoin safety information

Tretinoin is a topical retinoid and can cause dryness, redness, peeling, stinging or increased sensitivity, especially when treatment begins or the frequency is increased. This information is general product guidance, not a diagnosis or a personal treatment plan. For UK clinical guidance, see the NHS information on acne treatment.

  • Start low and slow. Many people begin on two non-consecutive nights a week, then increase only if their skin remains comfortable.
  • Use a pea-sized amount for the whole face, applied as a thin layer to clean, completely dry skin at night. Avoid the eyes, lips, corners of the nose and broken skin.
  • Use a bland moisturiser to support comfort. Avoid adding several exfoliating, peeling or drying products at the same time.
  • Use broad-spectrum sunscreen in the morning and limit unnecessary sun exposure. Tretinoin can make skin more sensitive to sunlight.
  • Mild dryness or flaking can occur. If burning, swelling, severe redness, blistering or persistent irritation develops, stop and seek advice from a pharmacist or doctor. Do not increase frequency to make up for missed applications.
  • Do not use topical tretinoin during pregnancy or when planning a pregnancy. If you become pregnant, stop and contact a healthcare professional. Do not use it while breastfeeding unless a healthcare professional has specifically advised you.
  • Do not apply tretinoin to cuts, sunburn, active eczema or other damaged skin. Ask a healthcare professional before use if you have a skin condition, use other retinoids, or take medicines that increase irritation or sun sensitivity.
Tretinoin frequency build-up schedule, from two nights a week to nightly use by week seven
A typical frequency build-up when starting tretinoin.

Frequently asked questions

Is tretinoin prescription-only in the UK?

Yes. Tretinoin is a prescription-only medicine in the UK. A UK prescriber can assess whether it is suitable and select a strength and formulation. This retailer is not a UK prescribing service. It sells internationally manufactured stock, so check the regulatory position and seek professional advice if you are unsure about using the product.

What is the best tretinoin strength for a beginner?

There is no single best strength for every beginner. A lower concentration is commonly discussed when starting because irritation risk depends on concentration, formulation, frequency and skin condition. Start only when the skin is intact, use a small amount infrequently, and ask a pharmacist or doctor to check whether tretinoin is appropriate for you.

Is 0.005% a real tretinoin strength?

0.005% is not the same as 0.05%. In UK searches, 0.005% is usually a misspelling of the commonly listed 0.05% strength, with one extra zero. Check the label carefully before ordering. The products on this page cover 0.025%, 0.05% and 0.1%. There is no 0.005% tretinoin product.

Is tretinoin cream or gel better?

Neither format is universally better. Cream and gel use different bases, and people can find one more comfortable than the other. The right choice depends on the product ingredients, your skin condition, previous tolerance and professional advice. Our guide on choosing cream vs gel covers the differences in detail.

Can I use tretinoin if my skin is sensitive or eczema-prone?

Use caution. Tretinoin can irritate sensitive skin and should not be applied to active eczema, cuts, sunburn or damaged skin. Wait until skin is intact and ask a pharmacist or doctor before starting. Stop and seek advice if severe redness, swelling, blistering or persistent burning occurs.

This page is product information, not medical advice. Tretinoin is a prescription-only medicine in the UK; speak to a pharmacist or doctor if you are unsure whether it is suitable for you.