Tretinoin 0.1% Microshere 20G Exp 01/2027

Tretinoin microsphere gel 0.1%: product summary

Tretinoin microsphere gel 0.1% is supplied as a 20G gel containing tretinoin at 0.1%. It is used in the management of acne in appropriate patients. The microsphere system encapsulates tretinoin and controls its release. The product name is spelled “Microshere”, while this page uses “microsphere” for readability.

Tretinoin is a prescription-only medicine in the UK. Internationally manufactured stock is sold through an international retail model. Check the rules where you live, including import requirements, and speak to a pharmacist or doctor before use, especially if pregnant, planning a pregnancy or breastfeeding. The expiry is 01/2027.

For a format comparison, see the tretinoin cream and gel comparison and the UK guide to buying tretinoin.

Last reviewed: September 2026.

Key facts

How it is generally used

Use the directions supplied with the gel and ask a pharmacist or doctor for advice. The steps below are general handling information, not an individual schedule.

1. Confirm the product name, 0.1% strength, 20G size and expiry before application.
2. Clean and dry the intended area. Apply only as directed and use a small, pea-sized amount if advised.
3. Start slowly if you are new to tretinoin and change frequency only with professional advice.
4. Avoid the eyes, lips, corners of the nose and broken or irritated skin.
5. Use sunscreen during the day and do not combine irritating active products without guidance.
6. Stop and seek advice if irritation is severe, persistent or accompanied by swelling.

The microsphere system provides controlled release of tretinoin. It does not ensure a particular result or prevent irritation. Do not apply extra gel or copy another person’s routine without professional guidance.

Who should speak to a clinician first

Ask a pharmacist or doctor before using this medicine if you are pregnant, planning a pregnancy or breastfeeding. Seek advice if you have significant sensitivity, an allergy, existing irritation or questions about combining treatments. A professional can help you decide whether a 0.1% microsphere gel is appropriate for your situation.

Frequently asked questions

What should I know about Tretinoin microsphere gel 0.1% in the UK?

This product is a 20G tretinoin microsphere gel at 0.1% strength, with an expiry of 01/2027. Tretinoin is prescription-only in the UK. Check local rules, including import requirements, and speak to a pharmacist or doctor before ordering or use. The stock is internationally manufactured and sold through an international retail model.

What does microsphere mean in this gel?

Microspheres encapsulate tretinoin within the gel and provide controlled release to the skin. That explains the delivery system, not whether irritation will occur or what result you will have. Follow the supplied directions and ask a pharmacist or doctor how the formulation fits your treatment plan.

What size and expiry does this product have?

The pack is 20G and the expiry is 01/2027. Check the date on the tube or packaging when it arrives. Do not use the gel after its expiry. If the packaging differs from these facts or the date is unclear, ask a pharmacist before use.

How should a new user approach tretinoin?

Start with professional advice and follow the supplied directions. General guidance is to apply a small amount to clean, dry skin, avoid sensitive areas, introduce the gel slowly and use sunscreen during the day. Stop and seek advice if severe irritation develops. Do not increase use to try to speed up results.

Can this gel be used during pregnancy or breastfeeding?

Speak to a pharmacist or doctor before using tretinoin during pregnancy, while planning a pregnancy or while breastfeeding. Do not make this decision from a product page alone. A clinician can review your circumstances and advise whether this medicine is suitable or whether another approach is needed.

Product information is not medical advice. Tretinoin is a prescription-only medicine in the UK. Internationally manufactured stock is sold through an international retail model. Check the rules where you live, including import requirements, and speak to a pharmacist or doctor before use, especially if pregnant, planning a pregnancy or breastfeeding.